Noggin Inhibits Postoperative Resynostosis in Craniosynostotic Rabbits
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چکیده
منابع مشابه
EXPERIMENTAL Anti-TGF- 2 Antibody Therapy Inhibits Postoperative Resynostosis in Craniosynostotic Rabbits
Pittsburgh, Pa.; Chapel Hill, N.C.; Columbus, Ohio; Los Angeles, Calif.; Ankara, Turkey; and Dallas, Texas Background: Postoperative resynostosis is a common clinical finding. It has been suggested that an overexpression of transforming growth factor (TGF)2 may be related to craniosynostosis and may contribute to postoperative resynostosis. Interference with TGF2 function with the use of neutra...
متن کاملPostoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits.
Postoperative resynostosis and secondary craniofacial growth abnormalities are common sequelae after craniofacial surgery. It has been suggested that an overexpression of transforming growth factor-beta2 (Tgf-beta2) may be related to craniosynostosis and contribute to postoperative resynostosis. Interference with Tgf-beta2 function using neutralizing antibodies may inhibit resynostosis and impr...
متن کاملComparison of craniofacial phenotype in craniosynostotic rabbits treated with anti-Tgf-beta2 at suturectomy site.
OBJECTIVE Overexpression of transforming growth factor-beta 2 has been associated with craniosynostosis and resynostosis following surgery. We examined the effects of localized transforming growth factor-beta 2 inhibition on craniofacial phenotype in rabbits with craniosynostosis. DESIGN Twenty-five New Zealand white rabbits with bilateral coronal craniosynostosis were divided into three trea...
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Timolol is a non-selective beta-adrenergic antagonist that is similar to propranolol. The mechanism through which these drugs act on the regression of neovascularization is largely unknown. However, it is thought that the drugs may act through vascular endothelial growth factor signaling, vasoconstriction, and vascular endothelial cell apoptosis. The aim of this study was to determine the effec...
متن کاملInterleukin-4 inhibits spontaneous sleep in rabbits.
Proinflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α, are involved in sleep regulation. IL-4 is an antiinflammatory cytokine that inhibits proinflammatory cytokine production. The hypothesis that IL-4 should attenuate sleep was studied by determining the effects of IL-4 on rabbit spontaneous sleep. Thirty-six rabbits were used. Four doses of IL-4 (0.25, 2.5, 2...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2007
ISSN: 0884-0431
DOI: 10.1359/jbmr.070410